منابع مشابه
Mutation in the Fas pathway impairs CD8+ T cell memory.
Fas death pathway is important for lymphocyte homeostasis, but the role of Fas pathway in T cell memory development is not clear. We show that whereas the expansion and contraction of CD8+ T cell response against Listeria monocytogenes were similar for wild-type (WT) and Fas ligand (FasL) mutant mice, the majority of memory CD8+ T cells in FasL mutant mice displayed an effector memory phenotype...
متن کاملFas/Fas ligand pathway
The orphan nuclear receptor Nur77/N10 has recently been demonstrated to be involved in apoptosis of T cell hybridomas. We report here that chronic expression of Nur77/N10 in thymocytes of transgenic mice results in a dramatic reduction of CD4+CD8+ double-positive as well as CD4+CD8and CD4-CD8+ single-positive cell populations due to an early onset ofapoptosis. CD4-CD8double-negative and CD25+ p...
متن کاملDeclarative memory consolidation: mechanisms acting during human sleep.
Of late, an increasing number of studies have shown a strong relationship between sleep and memory. Here we summarize a series of our own studies in humans supporting a beneficial influence of slow-wave sleep (SWS) on declarative memory formation, and try to identify some mechanisms that might underlie this influence. Specifically, these experiments show that declarative memory benefits mainly ...
متن کاملFas
Why all the fuss about Fas? Fas seems to be essential for killing off the immune response before it goes out of control. Mice bearing spontaneous loss-of-function mutations in Fas and FasL have enlarged spleens and lymph glands, and some mouse strains have a form of autoimmunity, due to a defect in the elimination of activated lymphocytes. Mutations in Fas have also been described in children w...
متن کاملStatus of FAS and FAS Ligand Gene Polymorphisms in Patients wi th Breast Cancer in Northeastern IRAN
Background: The First apoptosis signal (FAS) and First apoptosis signal ligand (FASL) genes initiate the apoptosis pathway, playing a central role in the tumor growth and metastasis. Gene polymorphisms including -1377 G/A in the promoter region of FAS and -844 C/T in the promoter region of FASL have shown to change the transcription activities of these genes. Methods: In this study we evalua...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2001
ISSN: 1534-5807
DOI: 10.1016/s1534-5807(01)00012-0